Meta-analysis for the effects of probiotic product Laktera with Lactobacillus bulgaricus on gastrointestinal tract
Summary
The probiotic product Laktera with Lactobacillus bulgaricus regulates and recovers the functions of the gastrointestinal tract and heals the internal human ecosystem.
The aim of Konstantin Ramshev and George Alexandrov from the Military Medical Academy in Sofia and Marieta Georgieva from the Medical University – Varna, is to prove the beneficial effects of a probiotic product Laktera with Lactobacillus bulgaricus on the human gastrointestinal tract.
Researchers have reviewed medical data published in Bulgarian and English languages in twenty two reports, exposés, dissertations and scientific articles for randomized controlled clinical studies on 2550 adult patients and therapeutic naïve individuals. These clinical studies were carried out within 31 years in Military Medical Academy, Medical Universities, Scientific Research Laboratories and Institutes in Member States of the European Union. The clinical studies were preceded by experimental trials on experimental animals. People, subject of these clinical studies were observed for adverse and toxic effects of the probiotic product for a subsequent period of over 10 years and such have not been registered.
The analysis includes clinical trials on humans for evaluation of the probiotic product Laktera with Lactobacillus bulgaricus as a part of tube and/or enteral feeding or part of a complex treatment regimen for sick people with various diseases and severe multiple organ damages and coma, for healthy people put to extreme physical and mental stress as well as pilots from the Air Force, military sailors and astronauts.
Results
Regular intake of the probiotic product Laktera with Lactobacillus bulgaricus as a part of a complex treatment and enteral feeding leads to a significant reduction of the damage of the gastrointestinal tract, described below with substantial statistical significance. The probiotic products Laktera with Lactobacillus bulgaricus are efficient in cases of the following damage of the functions of the gastrointestinal tract:
- Disorder of the functions of the gastrointestinal tract in case of space sickness of movement and extreme stress
- Disbacteriosis and disorders of the intestinal flora of different etiology
- Gastroenteritis and colitis of toxic, viral and allergic origin
- Impossibility of active food intake and hypoproteinaemia in comatose, early postoperative period, severe chemical burns and toxo-allergic damages (Lyell syndrome) of the gastrointestinal tract.
- Impaired digestion
- Upper dyspeptic syndrome
- Irritable Bowel Syndrome
- Increased flatulence
- Consumptive syndrome and hypoproteinaemia in late postoperative period and due to drug addiction
- Gastroenteritis and diarrhea as a result of infectious inflammatory damage to the gastrointestinal tract caused by Salmonella, Shigella, coliforms, Proteus and staphylococci
- Haematemesis of toxic origin (ethyl alcohol)
- Gastro-enteropathy as a result of lactase deficiency and lactose intolerance
- Gastro-enteropathy as a result of beta-galactosidase deficiency and galactose intolerance (galactosemia)
- Disorder of the intestinal motorics
- Ulcers and gastritis of toxic, toxo-allergic, corrosive or infectious origin (Helicobacter pylori) and stress ulcers in cases of thermal injury
Based on these findings the study authors conclude:
“The probiotic products Laktera with Lactobacillus bulgaricus have healing effect in cases of disorders of the gastrointestinal tract of various etiology and severity. Regular intake of the probiotic Laktera helps the maintenance of the activity and vitality of the human body, improves life quality and maintains the gastrointestinal health.”
Researchers: Associate professor Dr. Konstantin Ramshev chief of the Department of Intensive therapy and Reanimation, Military Medical Academy, Sofia, Dr. George Alexandrov, Military Medical Academy, Sofia, Department of Surgery and Associate professor Dr. Marieta Georgieva, Ph. d., Medical University, Varna, Department of Pharmacology.
Reference:
- Military Medical Academy, Medical University – Sofia, National Center of Hygiene, Medical Ecology and Nutrition, Medical University of Würzburg – Germany, Elbi-Bulgaricum, JSC; “Complex medical-biological studies of the effects of Biostim LBS on preventive and curative processes in people put to extreme overload in case of sea rescue operations, in Air Force pilots and navigators and patients with acute and chronic damages from drugs”; (136 patients)
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- Biostim LBS: a special-diet and therapeutic low-lactose powdered food product, Military Medical Academy, Sofia, ELBY Engineering-G State Company, Sofia, B. Gyosheva, N. Alexandrov and others, published in Biotechnology & BioE 6/1992/4 Appendix (100 patients);
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